Acetyl chloride → N'-Acetyl-6-chloronicotinohydrazide

HRID 254250Notes

Reaction equation

[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH2:9])=[O:7])=[CH:4][N:3]=1.[C:12](Cl)(=[O:14])[CH3:13]>>[C:12]([NH:9][NH:8][C:6](=[O:7])[C:5]1[CH:10]=[CH:11][C:2]([Cl:1])=[N:3][CH:4]=1)(=[O:14])[CH3:13]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 28001776-Chloropyridine-3-carbohydrazide

Product 1

HCID 30905803N'-Acetyl-6-chloronicotinohydrazideYield 64%

Procedure

The title compound was prepared from 6-chloronicotinic acid hydrazide and acetyl chloride, using the method of preparation 33, as a white solid in 64% yield.

Workup

customthe method of preparation 33

Sources & evidence

ORD record: ord-1a4bcb8e5ca04cb8bcafa698586e9bb2
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07875615B2

Reaction notes

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