1,2-Dichloroethane → HCID 16737313, compound

Participants

Reaction Steps

ylethyl)ureido]benzoic acid (obtained in Example 45) dissolved in dichloromethane are introduced into a 100 mL flask under an argon atmosphere, then HOBt (27 mg, 1.2 eq.), EDC (37 mg, 1.2 eq.), and ethanolamine (12 mg, 1 eq.) are added to the medium. After reacting for 14 hours, the mixture is neutralised with water, then with a saturated NaHCO3 solution and the aqueous phase is extracted with dichloromethane. The organic phases are combined and washed with brine, then, dried over MgSO4 and concentrated. The crude product thus obtained is purified by silica column chromatography (eluent: CH2Cl2/MeOH 99/1 to 96/4). The desired amide, 3-[3-(3,3-diphenylpropyl)-3-(2-morpholin-4-ylethyl)ureido]-N-(2-hydroxyethyl)benzamide, is obtained in a yield of 52%. This procedure is hereinafter called method “J”, route 2.

Provenance & Evidence