Ammonia → HCID 42630801, compound

HRID 254284Notes

Reaction equation

HRID 254284 reaction equation
Cl[C:2]1[C:3]2[N:4]([C:13]([CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)=[N:14][C:15]=2[CH3:16])[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[C:7]([F:12])[CH:6]=2.[NH3:23]>>[CH:17]1([C:13]2[N:4]3[C:5]4[C:10]([N:11]=[C:2]([NH2:23])[C:3]3=[C:15]([CH3:16])[N:14]=2)=[CH:9][CH:8]=[C:7]([F:12])[CH:6]=4)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 86630791HCID 86630791, compound

Product 1

HCID 42630801HCID 42630801, compound

Procedure

640 mg 4-Chloro-1-cyclohexyl-8-fluoro-3-methyl-imidazo(1,5-a)quinoxaline (2 mmol) and 30 ml 32% aqueous ammonia were heated 7 hours at 130-135° C. After cooling the product was filtered off, washed with water, dried and chromatographed on silica gel with 2% MeOH/CH2Cl2.

Workup

  1. temperatureAfter cooling the product
  2. filtrationwas filtered off
  3. washwashed with water
  4. customdried
  5. customchromatographed on silica gel with 2% MeOH/CH2Cl2

Sources & evidence

ORD record
ord-124f563a84ec4ddd84c54d663c1c9367
Source dataset
uspto-grants-2011_01
Patent number
US07875618B2

Reaction notes

Loading…