Water → HCID 42629228, compound

HRID 254289Notes

Reaction equation

HRID 254289 reaction equation
Cl[C:2]1[C:3]2[N:4]([C:13]([CH2:17][CH2:18][CH3:19])=[N:14][C:15]=2[CH3:16])[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[C:7]([F:12])[CH:6]=2.[OH-:20].[K+].Cl[CH2:23]Cl.O>CO>[F:12][C:7]1[CH:6]=[C:5]2[C:10]([N:11]=[C:2]([O:20][CH3:23])[C:3]3[N:4]2[C:13]([CH2:17][CH2:18][CH3:19])=[N:14][C:15]=3[CH3:16])=[CH:9][CH:8]=1

Participants

6

Reactant 4

HCID 962WaterHCID 6344DichloromethaneHCID 14797Potassium HydroxideHCID 86630793HCID 86630793, compound

Product 1

HCID 42629228HCID 42629228, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

560 mg 4-Chloro-8-fluoro-3-methyl-1-propyl-imidazo(1,5-a)quinoxaline (2 mmol) were dissolved in 10 ml methanol and 500 mg potassium hydroxide were added. The reaction was heated to reflux for 2 hours, cooled, and distributed between 50 ml dichloromethane and 20 ml water. The separated water phase was extracted again with 50 ml dichloromethane. The combined organic layers were washed with 25 ml water and distilled to dryness.

Workup

  1. temperatureThe reaction was heated
  2. temperatureto reflux for 2 hours
  3. temperaturecooled
  4. extractionThe separated water phase was extracted again with 50 ml dichloromethane
  5. washThe combined organic layers were washed with 25 ml water
  6. distillationdistilled to dryness

Sources & evidence

ORD record
ord-e3ef0a1d990f456483d56a4b93418b65
Source dataset
uspto-grants-2011_01
Patent number
US07875618B2

Reaction notes

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