HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 42629356, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) | HCID 2777204 | — |
| Reactant | 1-Bromo-8-fluoro-3,4-dimethylimidazo[1,5-a]quinoxaline | HCID 57732452 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | HCID 42629356 | HCID 42629356 | 85.3% |
Reaction Steps
Following the general Suzuki coupling procedure, reaction of bromide 5A (75 mg, 0.25 mmol), 2-trifluoromethoxyphenylboronic acid (62 mg, 0.30 mmol), K2CO3 (105 mg, 0.75 mmol) and Pd(PPh3)4 (5.8 mg, 0.005 mmol) provided the coupling product as a white powder (80 mg, 85% yield). EIMS 376.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07875618B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-9ca0ead64234402e9320faf1799b6c13 |
| Source note | uspto-grants-2011_01 |