HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-(2-Chloro-4-fluorophenyl)-6-fluoro-8-methoxy-3,4-dimethylimidazo[1,5-a]quinoxaline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-4-fluorobenzeneboronic acid | HCID 17750229 | — |
| Reactant | 1-Bromo-6-fluoro-8-methoxy-3,4-dimethylimidazo[1,5-a]quinoxaline | HCID 57732464 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 1-(2-Chloro-4-fluorophenyl)-6-fluoro-8-methoxy-3,4-dimethylimidazo[1,5-a]quinoxaline | HCID 42629476 | 20.1% |
Reaction Steps
Following the general Suzuki coupling procedure, reaction of bromide 6A (65 mg, 0.2 mmol), 2-chloro-4-fluorophenylboronic acid (52 mg, 0.3 mmol), K2CO3 (82 mg, 0.6 mmol) and Pd(PPh3)4 (5 mg, 0.004 mmol) provided the coupling product as an off-white powder (15 mg, 20% yield). EIMS 374.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07875618B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-b42f4c598edc485c992eb03fea276b47 |
| Source note | uspto-grants-2011_01 |