Dimethylformamide → HCID 42629828, compound

Participants

Role	Name	HCID	Charge
Reactant	Dimethylformamide	HCID 6228	—
Reactant	Cesium carbonate	HCID 10796	—
Reactant	2-(Bromomethyl)-1,3-difluorobenzene	HCID 581435	—
Reactant	HCID 42629710	HCID 42629710	—
Solvent	Water	HCID 962	—
Product	HCID 42629828	HCID 42629828	—

Reaction Conditions

Temperature	130 °C

Reaction Steps

1 g 1-(2-Chloro-phenyl)-3,4-dimethyl-7-hydroxy-imidazo(1,5-a)quinoxaline, 2.24 g Caesium carbonate, 50 mL N,N-dimethylformamide, and 6 mL water were stirred for 10 min followed by addition of 0.83 g 2,6-difluorobenzylbromide. After 3 h stirring at 130° C. the reaction mixture was given into 150 mL water, filtered off, washed with water, dried under reduced pressure, and purified with silica gel, dichloromethane/methanol=95/5.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07875618B2
Source dataset	uspto-grants-2011_01
ORD ID	ord-720b6c95d79744c5b9668e0edb6b7010
Source note	uspto-grants-2011_01