Methanol → HCID 42630070, compound

HRID 254319Notes

Reaction equation

HRID 254319 reaction equation
[Br:1][C:2]1[N:6]2[C:7]3[C:12]([N:13]=[C:14]([CH3:15])[C:5]2=[C:4]([CH3:18])[N:3]=1)=[C:11]([F:16])[CH:10]=[C:9]([F:17])[CH:8]=3.[CH3:19][OH:20]>>[F:16][C:11]1[CH:10]=[C:9]([F:17])[CH:8]=[C:7]2[C:12]=1[N:13]=[C:14]([CH3:15])[C:5]1[N:6]2[C:2]([O:20][CH3:19])=[N:3][C:4]=1[CH3:18].[Br:1][C:2]1[N:6]2[C:7]3[C:12]([N:13]=[C:14]([CH3:15])[C:5]2=[C:4]([CH3:18])[N:3]=1)=[C:11]([F:16])[CH:10]=[C:9]([F:17])[CH:8]=3

Participants

4

Reactant 2

HCID 887MethanolHCID 57732461HCID 57732461, compound

Product 2

HCID 42630070HCID 42630070, compoundHCID 57732461HCID 57732461, compound

Procedure

Examples 70-73 were prepared according to the general Suzuki coupling procedure Example 19 using 1-bromo-6,8-difluoro-3,4-dimethylimidazo[1,5-a]quinoxaline (8A). Example 73 6,8-difluoro-1-methoxy-3,4-dimethylimidazo[1,5-a]quinoxaline was obtained from 1-bromo-6,8-difluoro-3,4-dimethylimidazo[1,5-a]quinoxaline (8A) and methanol (stirred for 2 hours at room temperature).

Workup

  1. customExamples 70-73 were prepared

Sources & evidence

ORD record
ord-a2552ee0009948c1b6274cdd5831e646
Source dataset
uspto-grants-2011_01
Patent number
US07875618B2

Reaction notes

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