Nitric Acid → HCID 14473250, compound

To 1-fluoro-3-trifluoromethoxybenzene (1 mL) was added concentrated sulfuric acid (1 mL) at 0° C. To the cold solution was added dropwise (0.7 mL) of a solution made from concentrated nitric acid (1 mL) and concentrated sulfuric acid (1 mL). The reaction was slowly allowed to warm to room temperature then poured onto ice and extracted with ether. The organic layer was separated and washed with sodium hydroxide 1N, then brined and dried over magnesium sulfate. The solvent was removed under reduce pressure at room temperature. A pale yellow oil (1 g) was recovered and used without further purification.

1. additionthen poured onto ice
2. extractionextracted with ether
3. customThe organic layer was separated
4. washwashed with sodium hydroxide 1N
5. dry with materialdried over magnesium sulfate
6. customThe solvent was removed
7. customat room temperature
8. customA pale yellow oil (1 g) was recovered
9. customused without further purification

ORD record

ord-ec1bb395d60b45e989a6646a36bd8ca7

Source dataset

uspto-grants-2011_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07875618B2