Benzenamine, 2-chloro-4-fluoro- → 4-[(2-chloro-4-fluorophenyl)amino]-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one

Participants

Reaction Conditions

Reaction Steps

[1,1′]-Bipiperidinyl-2,4-dione (2.00 g, 10.19 mmol) was dissolved in toluene (8 ml) and 2-chloro-4-fluorophenylamine (1.78 g, 12.23 mmol) was added. More toluene (5 ml) was added. The reaction mixture was boiled under reflux at 110° C. for 17 h then allowed to cool. When the reaction mixture reached rt the product precipitated and it was collected by filtration to yield a beige solid (1.80 g, 55%).

Provenance & Evidence