{4-[4-(3-Carbamoylpropylamino)phenyl]butyl}carbamic acid tert-butyl ester → 4-[4-(4-Aminobutyl)phenylamino]butyramide

Participants

Reaction Steps

{4-[4-(3-Carbamoylpropylamino)phenyl]butyl}carbamic acid tert-butyl ester 430 (0.23 g, 0.66 mmol) was cooled to 0° C. in an ice bath. A cold solution of TFA/dichloromethane (10 mL) was added. The reaction was slowly warmed to room temperature and stirred for 30 minutes. The solvent was evaporated in vacuo to provide 440. 1H NMR (300 MHz, CD3OD) δ 1.69 (m, 4H), 1.95 (m, 2H), 2.47 (m, 2H), 2.71 (m, 2H), 2.93 (m, 2H), 3.39 (m, 2H), 7.39 (s, 4H). m/z (ESI) 250.

Provenance & Evidence