HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 254399Generated: October 30, 2026
Toluene → [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]sulfanylmethanethioic S-acid
https://huagongshe.com/reaction/254399
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 8-Azabicyclo(3.2.1)octan-3-ol, 8-methyl-, 3-methanesulfonate | HCID 141951 | — |
| Reactant | Sodium ethylxanthate | HCID 23690437 | — |
| Solvent | Water | HCID 962 | — |
| Product | [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]sulfanylmethanethioic S-acid | HCID 71776021 | — |
Reaction Steps
Tropine-3-mesylate (25 g, 0.114 mol) and sodium ethylxanthate (19.7 g, 0.137 mol) were added to stirred toluene (0.075 L) under nitrogen. The stirred mixture was maintained at 30° C. for 6 h. Water (0.05 L) was added and after 15 min stirring the phases were separated. The toluene phase, containing the title compound, was used directly in the preparation of tropine-3-thiol as in Step 4b.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07875630B2 |
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| Source dataset | uspto-grants-2011_01 |
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| ORD ID | ord-19343e8ef019472f82defc9b4e1d2ca4 |
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| Source note | uspto-grants-2011_01 |
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