HCID 86613972, compound → HCID 86613973, compound

Participants

Reaction Steps

PdCl2 (40 mg) was added to a solution of the allyl ether (26) (394 mg, 241 μmol) in MeOH (10 mL) and 1,2-DCE (10 mL) and the combined mixture was heated (70°, 60 min). After the time, the solvents were evaporated and the residue subjected to FC (20-30% EtOAc/hexanes) to yield the alcohol (27) as a colourless oil (317 mg, 84%). 1H NMR (CDCl3) δ 3.67-3.82, 3.91-3.99, 4.01-4.21, 4.29-4.71 (4 m, 21H; H-2I,-3I,-4I,-5I,-6aI,-6bI,-3II,-5II,-6aII,-6bII,-3III,-5III,-6aIII,-6bIIICH2Ph), 4.83 (d, 1H, JA,B 10.9 Hz; A of AB quartet), 5.03-5.05 (m, 2H; H-1I,-2II), 5.25-5.28 (m, 2H; H-1II,-1III), 5.63 (dd, 1H, J3,4=J4,5 9.9 Hz; H-4II), 5.77 (dd, 1H, J1,2 2.0, J2,3 3.1 Hz; H-2III), 5.92 (dd, 1H, J3,4 9.7, J4,5 9.9 Hz; H-4III), 6.99-7.62, 7.80-8.16 (2 m, 50H; Ar).

Provenance & Evidence