Dimethyl Sulfoxide → HCID 86619199, compound

HRID 254451Notes

Reaction equation

HRID 254451 reaction equation
Br[C:2]1(Br)[C:6]([O:7][CH3:8])=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[N:4]([C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:17]=2[Cl:23])[NH:3]1.[OH2:25].[CH3:26]S(C)=O>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([C:5]2[N:4]([C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:17]=3[Cl:23])[N:3]=[C:2]([CH:26]=[O:25])[C:6]=2[O:7][CH3:8])=[CH:10][CH:11]=1

Participants

4

Reactant 3

HCID 679Dimethyl SulfoxideHCID 962WaterHCID 66839338HCID 66839338, compound

Product 1

HCID 86619199HCID 86619199, compound

Conditions

Temperature
120 °C

Procedure

Under nitrogen, 5 g of the 3,3-dibromo-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methoxy-1H-pyrazole obtained in stage G is placed in 30 ml of DMSO, and it is heated at 120° C. for 6 hours. The reaction mixture is poured into 100 ml of water and it is extracted twice with 100 ml of AcOEt. The organic phase is washed with 100 ml of saturated NaCl and then dried over Na2SO4. After evaporating to dryness, 4 g of the unpurified expected compound is obtained.

Workup

  1. extractionis extracted twice with 100 ml of AcOEt
  2. washThe organic phase is washed with 100 ml of saturated NaCl
  3. dry with materialdried over Na2SO4
  4. customAfter evaporating to dryness

Sources & evidence

ORD record
ord-6a1fb9310b0c4b878e518f55dfb5f39c
Source dataset
uspto-grants-2011_01
Patent number
US07875646B2

Reaction notes

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