反应详情

To 20 ml ethylene diamine were added at 0° C. 3.20 g (10 mmol) 2-(2,2-dibromo-vinyl)-1,3-diethyl-benzene and the mixture stirred at ambient temperature for 16 hours. The reaction was quenched by addition of aqueous 2N ammonia, extracted with ethyl acetate, the combined extracts washed with brine, dried over Na2SO4, filtered and evaporated. The residue was dissolved in ethyl acetate and crystallization at −10° C. provided 2.85 g 2-(2,6-diethyl-benzyl)-4,5-dihydro-1H-imidazole as colourless solid: MS (ISP): 217.1 ((M+H)+.).

1. customThe reaction was quenched by addition of aqueous 2N ammonia
2. extractionextracted with ethyl acetate
3. washthe combined extracts washed with brine
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. customevaporated
7. dissolutionThe residue was dissolved in ethyl acetate
8. customcrystallization at −10° C.