HCID 178436445, compound → HCID 178436246, compound

HRID 254472Notes

Reaction equation

HRID 254472 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5](OC)[C:4]=1/[CH:11]=[N:12]/[CH:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15])[CH3:2].[CH2:20]([Li])[CH:21]([CH3:23])[CH3:22]>>[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:20][CH:21]([CH3:23])[CH3:22])[C:4]=1/[CH:11]=[N:12]/[CH:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15])[CH3:2]

Participants

3

Reactant 2

HCID 178436445HCID 178436445, compoundHCID 178506859HCID 178506859, compound

Product 1

HCID 178436246HCID 178436246, compound

Procedure

(E)-[1-(2-Ethyl-6-isobutyl-phenyl)-methylidene]-(1-isopropyl-2-methyl-propyl)-amine was prepared from (E)-[1-(2-ethyl-6-methoxy-phenyl)-methylidene]-(1-isopropyl-2-methyl-propyl)-amine (Example 3 a) and isobutyl lithium in analogy to procedure Example 5 a): colourless liquid; NMR (CDCl3, ppm): 0.88 t, 18H (2×(CH3)2C), 1.20 t, 3H(CH3—CH2), 1.88 septett, 1H(CH(CH3)2), 2.08 m, 2H(NCH(CH(CH3)2)2), 2.48 t, 1H(NCH), 2.68 d, 2H (aryl -CH2CH), 2.88 q, 2H(CH3-CH2), 7.00 d, 1H and 7.08 d, 1H and 7.19 t, 1H (aryl-H), 8.49 1H (═CHN).

Sources & evidence

ORD record
ord-19be7ef0983c4ccba0513dfa413cc7e6
Source dataset
uspto-grants-2011_01
Patent number
US07875645B2

Reaction notes

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