HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Cyanide → 2-Fluoro-5-methylphenylacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 15-Crown-5 | HCID 36336 | — |
| Reactant | 2-(Bromomethyl)-1-fluoro-4-methylbenzene | HCID 17750800 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-Fluoro-5-methylphenylacetonitrile | HCID 17750676 | — |
Reaction Steps
(2-Fluoro-5-methyl-phenyl)-acetonitrile was prepared from 2-bromomethyl-1-fluoro-4-methyl-benzene and sodium cyanide in presence of a catalytic amount of 15-crown-5 in acetonitrile at ambient temperature over night in analogy to R. B. Katz et al., Tetrahedron 45, 1801 (1989): light yellow liquid; MS (EI): 149.1 (M+.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07875645B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-8b2c5edc129c46168a3c157486cb367d |
| Source note | uspto-grants-2011_01 |