HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 58951910, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Ethylenediamine | HCID 3301 | — |
| Reactant | 2-Fluoro-5-(Trifluoromethyl)Phenylacetonitrile | HCID 2737598 | — |
| Reactant | Trimethylaluminum | HCID 16682925 | — |
| Product | HCID 58951910 | HCID 58951910 | — |
Reaction Steps
2-(5-Fluoro-2-trifluoromethyl-benzyl)-4,5-dihydro-1H-imidazole was prepared from (2-fluoro-5-trifluoromethyl-phenyl)-acetonitrile and the complex of trimethylaluminium with ethylene diamine in toluene at reflux for 18 hours in analogy to M. P. Wentland et al., J. Med. Chem. 30, 1482 (1987): brown solid; MS (ISP): 247.0 ((M+H)+.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07875645B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-f340f0de59b54a45a6c7e90c4adf533e |
| Source note | uspto-grants-2011_01 |