Ethylenediamine → Rac-2-[1-(2-iodo-phenyl)-ethyl]-4,5-dihydro-1h-imidazole

HRID 254524Notes

Reaction equation

[I:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([CH3:11])[C:9]#[N:10].[CH2:12](N)[CH2:13][NH2:14]>>[I:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([C:9]1[NH:14][CH2:13][CH2:12][N:10]=1)[CH3:11]

Participants

Reactant 2

HCID 3301Ethylenediamine

HCID 668551472-(2-Iodophenyl)propanenitrile

Product 1

HCID 58951897Rac-2-[1-(2-iodo-phenyl)-ethyl]-4,5-dihydro-1h-imidazole

Procedure

rac-2-[1-(2-Iodo-phenyl)-ethyl]-4,5-dihydro-1H-imidazole was prepared from rac-2-(2-iodo-phenyl)-propionitrile and ethylene diamine in analogy to Example 19 b): white solid; MS (EI): 301.0 ((M+H)+.).

Sources & evidence

ORD record: ord-5ef718b6dc5c43e69db85cf32b3a30d2
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07875645B2

Reaction notes

Loading…