HCID 178418443, compound → HCID 178448986, compound

HRID 254565Notes

Reaction equation

HRID 254565 reaction equation
[CH2:1](/[N:5]=[CH:6]/[C:7]1[C:12]([F:13])=[CH:11][CH:10]=[C:9]([F:14])[C:8]=1Cl)[CH2:2][CH2:3][CH3:4].[CH2:16]([Mg]Br)[CH3:17]>[Cl-].[Mn+2].[Cl-]>[CH2:1](/[N:5]=[CH:6]/[C:7]1[C:12]([F:13])=[CH:11][CH:10]=[C:9]([F:14])[C:8]=1[CH2:16][CH3:17])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 178418443HCID 178418443, compoundHCID 178448987HCID 178448987, compound

Product 1

HCID 178448986HCID 178448986, compound

Reagents, catalysts & solvents 1

HCID 10313134Manganese(2+) dichlorideCatalyst

Procedure

Butyl-[1-(2-ethyl-3,6-difluoro-phenyl)-meth-(E)-ylidene]-amine was prepared from butyl-[1-(2-chloro-3,6-difluoro-phenyl)-meth-(E)-ylidene]-amine, ethylmagnesium bromide and manganese(II) chloride in analogy to Example 194a): brown oil; 1H-NMR (CDCl3): 0.97 (3H, t, CH3), 1.15 (3H, t, CH3), 1.43 (2H, sextet, CH2), 1.70 (2H, quintet, CH2), 2.98 (2H, qd, CH2), 3.66 (2H, t, CH2), 6.87 (1H, td, ArH), 6.99 (1H, td, ArH), 8.52 (1H, s, CH═N).

Sources & evidence

ORD record
ord-a9080da8e8e34e01ab4faaf119eb8388
Source dataset
uspto-grants-2011_01
Patent number
US07875645B2

Reaction notes

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