HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178490666, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-Chloro-o-anisic acid | HCID 76970 | — |
| Reactant | 1-((5-tert-butyl-2-iminothiazol-3(2H)-yl)methyl)cyclohexanol | HCID 66851825 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178490666 | HCID 178490666 | 51.4% |
Reaction Steps
The product of Example 20A (1.3 g, 3.7 mmol), 5-chloro-2-methoxybenzoic acid (0.70 g, 3.7 mmol), thionyl chloride (10 mL) and triethylamine (1.6 mL, 11 mmol) in THF (25 mL) were processed as described in Example 18B and Example 18C to provide the title compound (0.82 g, 1.9 mmol, 50% yield). MS (DCI/NH3) m/z 437 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07875640B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-ec2b8adfa7e344f6ac99834959cb9697 |
| Source note | uspto-grants-2011_01 |