HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 178490662, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 5-Chloro-o-anisic acid | HCID 76970 | — |
| Reactant | tert-butyl 3-((5-tert-butyl-2-iminothiazol-3(2H)-yl)methyl)azetidine-1-carboxylate | HCID 66660694 | — |
| Product | HCID 178490662 | HCID 178490662 | — |
Reaction Steps
The title compound was prepared according to the procedure described in Example 54A by substituting 5-chloro-2-methoxybenzoic acid for Example 26B and the product of Example 63A for Example 16A. 1H NMR (300 MHz, CHLOROFORM-D) δ ppm 1.34 (s, 9H) 1.44 (s, 9H) 3.10-3.30 (m, 1H) 3.77 (dd, J=9.12, 5.16 Hz, 2H) 3.90 (s, 3H) 4.05 (t, J=8.53 Hz, 2H) 4.37 (s, 2H) 6.63 (s, 1H) 6.91 (d, J=8.73 Hz, 1H) 7.33 (dd, J=8.72, 2.78 Hz, 1H) 7.89 (d, J=2.78 Hz, 1H). MS (DCI/NH3) m/z 494.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07875640B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-41b882811aba4ca6b41b8c5eddcdd3a3 |
| Source note | uspto-grants-2011_01 |