HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → 3-(cyclobutylmethyl)-4,4,6,6-tetramethyl-4,6-dihydrofuro[3,4-d]thiazol-2(3H)-imine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | 2,2,5,5-Tetramethyltetrahydro-3-ketofuran | HCID 138511 | — |
| Reactant | Potassium thiocyanate | HCID 516872 | — |
| Reactant | 1-Cyclobutylmethanamine hydrochloride | HCID 21707944 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 3-(cyclobutylmethyl)-4,4,6,6-tetramethyl-4,6-dihydrofuro[3,4-d]thiazol-2(3H)-imine | HCID 66852127 | — |
Reaction Steps
Commercially available 2,2,5,5-tetramethyldihydrofuran-3(2H)-one (Aldrich), triethylamine, cyclobutylmethanamine hydrochloride (prepared from cyclobutanecarbonitrile as described in WO2005075464), potassium thiocyanate (Aldrich) and iodine (EMD chemicals) were processed using the method described in Example 91A to afford the title compound. MS (ESI+) m/z 267 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07875640B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-5920738ea4e24b7aad59752f8268b4db |
| Source note | uspto-grants-2011_01 |