(5-Methoxypyridin-2-yl)methanol → 2-Formyl-5-methoxypyridine

Participants

Reaction Steps

To a solution of 5.7 g (41 mmol) (5-methoxypyridin-2-yl)methanol in 100 mL CHCl3 was added 15 g MnO2 and the mixture heated to reflux for 2 hours, filtered, and washed with boiling CHCl3. The filtrate was washed with brine, dried over MgSO4, and concentrated in vacuo to afford 5-methoxypyridine-2-carbaldehyde as a white solid. 1H NMR (400 MHz, CDCl3) δ 9.99 (s, 1H), 8.44 (d, J=2.4 Hz, 1H), 7.97 (d, J=8.4 Hz, 1H), 7.3 (dd, J=8.4, 2.4 Hz, 1H), 3.95 (s, 2H).

Provenance & Evidence