HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glutaric anhydride → Succinimide glutarate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glutaric anhydride | HCID 7940 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | N-Hydroxysuccinimide | HCID 80170 | — |
| Reactant | Glutarate(2-) | HCID 4418048 | — |
| Product | Succinimide glutarate | HCID 86592295 | — |
Reaction Steps
As depicted in above Scheme 2, 6-arm PEG (1) synthesized in the Scheme 1 is reacted with glutarate reagents, e.g., glutaric anhydride to synthesize 6-arm PEG-glutatic acid (6-arm PEG-GA) (2). The compound (2) was reacted with N-hydroxy succinimide (NHS) and N, N′-dicyclohexylcarbodiimide (DCC) to produce 6-arm PEG-succinimide glutarate (6-arm PEG-SG) (3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06858736B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-21362a60159840c9abdcc13b32c63fc9 |
| Source note | uspto-grants-2005_02 |