참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Tolylboronic acid | HCID 2733950 | — |
| 반응물 | 1-(4-Bromophenyl)-2,2,2-trifluoroethanol | HCID 11219024 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2,2,2-Trifluoro-1-(3'-methylbiphenyl-2-yl)ethanol | HCID 66649251 | 72% |
반응 단계
1-(4-Bromophenyl)-2,2,2-trifluoroethanol (0.13 g, 0.525 mmol), m-tolylboronic acid (0.1 g, 0.736 mmol), Fibercat (4.28% Pd, 47 mgs, 0.0157 mmol Pd), K2CO3 (0.22 g, 1.576 mmol), EtOH (3 mls), and H2O (0.5 mls) were combined and heated at 80° C. for 4 hours. The reaction was shown complete by TLC (CH2Cl2). The mixture was cooled, filtered, concentrated, slurried in CH2Cl2, and chromatographed over silica gel (CH2Cl2) to give 0.1 g of 2,2,2-trifluoro-1-(3′-methylbiphenyl-2-yl)ethanol. Yield: 72%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07875622B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_01 |
|---|
| ORD ID | ord-5d05271ca8e549d09a512f7dbdb17405 |
|---|
| 출처 메모 | uspto-grants-2011_01 |
|---|
