Diethyl Ether → HCID 66862433, compound

Participants

Reaction Steps

To a solution of the azide 63 (110.2 mmol) in dry DMF (275 mL) was added dithiothreitol (220.4 mmol). The reaction mixture was then degassed with a stream of nitrogen, cooled to 0 C, and triethylamine (220.4 mmol) added. The solution was then allowed to return to room temperature and subsequently stirred for 24 h. The solution was then diluted with ethyl acetate and washed with water, brine, dried (MgSO4), the solvents removed in vacuo, and resulting residue treated with diethyl ether (˜250 mL) to give the desired product 64 as a white solid (69%), LCMS [M+H]+=540.25.

Provenance & Evidence