HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyamine hydrochloride → 5-Tert-butylisoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | HCID 178429089 | HCID 178429089 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Tert-butylisoxazole | HCID 3304353 | 34% |
| Product | 3-(1,1-Dimethylethyl)isoxazole | HCID 13740233 | 14% |
Reaction Steps
A solution of diketone (87) (200 mg, 0.43 mmol) and hydroxylamine hydrochloride (60 mg, 0.86 mmol) in EtOH (5 mL) was irradiated in a microwave reactor (Biotage) for 20 min. at 140° C. Purification by Prep-LC (Gilson) provided 67 mg (34%) of 5-t-butylisoxazole and 28 mg (14%) of 3-t-butylisoxazole as solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07875647B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-7a44d0548f024378b6ec41fd317817b8 |
| Source note | uspto-grants-2011_01 |