Benzoic Acid → HCID 86602151, compound

Participants

Reaction Steps

A mixture of 4-(oxiran-2-ylmethoxy)-9H-carbazole (II) (25.0 g, 104.60 mmole) and 62.5 ml 2-propanol is heated to 70° C. to 80° C. To this 2-(2-methoxyphenoxy)ethylamine (III) (25.33 g, 151.67 mmole) is added in one lot. The temperature of reaction mass is raised to reflux (80° C. to 85° C.) and maintained at this temperature for 1 hour. After that, this reaction mass was added to the pre-heated (80° C. to 85° C.) solution of benzoic acid (18.5 g) in 2-propanol (287.5 ml) and continued the reflux for next 2-hour, cooled to 50° C. to 55° C. and maintained the same temperature for 1 hr. The product filtered at same temperature followed by three 33.5 ml wash with hot (50° C. to 55° C.) 2-propanol. The wet product dried at 60° C. to 65° C. for 6-8 hours or till constant weight gives 36.5 g of Carvedilol benzoate (Yield=66%).

Provenance & Evidence