Chloroform → N-ethoxymethyl-N-methylpyrrolidinium hexafluorophosphate

HRID 254902Notes

Reaction equation

HRID 254902 reaction equation
[Cl-].[CH2:2]([O:4][CH2:5][N+:6]1([CH3:11])[CH2:10][CH2:9][CH2:8][CH2:7]1)[CH3:3].[F:12][P-:13]([F:18])([F:17])([F:16])([F:15])[F:14].[Na+].C(Cl)(Cl)Cl>O>[F:12][P-:13]([F:18])([F:17])([F:16])([F:15])[F:14].[CH2:2]([O:4][CH2:5][N+:6]1([CH3:11])[CH2:10][CH2:9][CH2:8][CH2:7]1)[CH3:3]

Participants

5

Reactant 3

HCID 6212ChloroformHCID 5147921Sodium hexafluorophosphateHCID 23116054N-ethoxymethyl-N-methylpyrrolidinium chloride

Product 1

HCID 86618684N-ethoxymethyl-N-methylpyrrolidinium hexafluorophosphateYield 66.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In 70.00 g of water was dissolved 35.00 g of N-ethoxymethyl-N-methylpyrrolidinium chloride and thereto was added 32.70 g of sodium hexafluorophosphate to obtain a white solid. The mixture was stirred for 30 minutes, and chloroform was added to the mixture for extraction. The extract was washed with 50 g of water 15 times, thereafter dried, giving 37.50 g of the desired product in the form of a white solid. The product was checked for 1H-NMR as in Example 1.

Workup

  1. customto obtain a white solid
  2. washThe extract was washed with 50 g of water 15 times
  3. customdried

Sources & evidence

ORD record
ord-75f1e97b9fbd4866970b1db612a1b356
Source dataset
uspto-grants-2011_01
Patent number
US07875732B2

Reaction notes

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