反应详情

To a mixture of the product from Step C, 2-(4,5-difluoro-2-nitro-phenyl)-1-(4-methoxy-3-nitro-phenyl)-ethanone (4.00 g, 11.3 mmol) in glacial acetic acid (100 mL) was added in portions zinc dust (28 g, 325 mesh) at 0° C. Upon adding a few portions of zinc, the reaction mixture became a solid mass. The cooling bath was removed, and the remaining zinc was added in portions; the cooling bath was replaced, and stirring was continued for 1 hour at 0° C. and 1 hour at room temperature. The zinc metal was removed by filtration and the metal was washed with ethyl acetate. The organic solution was concentrated to dryness and the residue was partitioned between ethyl acetate (200 mL) and saturated aqueous sodium bicarbonate solution (200 mL). The layers were separated, the organic layer washed with brine, dried (magnesium sulfate), filtered, and concentrated to a tan solid. The solid was triturated with hexanes/ethyl acetate, 15/1, v/v and the insoluble portion collected by filtration (2.35 g), mp 210-211° C.

1. customThe cooling bath was removed
2. additionthe remaining zinc was added in portions
3. customThe zinc metal was removed by filtration
4. washthe metal was washed with ethyl acetate
5. concentrationThe organic solution was concentrated to dryness
6. customthe residue was partitioned between ethyl acetate (200 mL) and saturated aqueous sodium bicarbonate solution (200 mL)
7. customThe layers were separated
8. washthe organic layer washed with brine
9. dry with materialdried (magnesium sulfate)
10. filtrationfiltered
11. concentrationconcentrated to a tan solid
12. customThe solid was triturated with hexanes/ethyl acetate, 15/1, v/v
13. filtrationthe insoluble portion collected by filtration (2.35 g), mp 210-211° C.