HCID 66862603, compound → HCID 66862362, compound

Participants

Reaction Steps

Using the compound produced in Example 34 instead of the compound produced in Example 18, procedures similar to Example 19 were carried out, and to a methanol (5 ml) solution of the resulting ethyl(2E)-3-(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)(hydroxy)methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acrylate (39 mg), 10% palladium-carbon (8 mg) was added. The mixture was stirred under hydrogen gas atmosphere at room temperature for 8 hours. The reaction mixture was filtered, and the filtrate was concentrated to give the title compound (39 mg) having the following physical properties.

Provenance & Evidence