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Hydrazine hydrate (1:1) → 3-Fluoro-4-morpholin-4-ylmethylphenylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 4-(2-Fluoro-4-nitrobenzyl)morpholine | HCID 21955027 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Tetrahydrofuran ethanol | HCID 21873804 | — |
| 生成物 | 3-Fluoro-4-morpholin-4-ylmethylphenylamine | HCID 21955013 | 94% |
反応手順
To a solution of 4-(2-fluoro-4-nitrobenzyl)morpholine (240 mg, 1.0 mmol) in THF/ethanol mixture (1:1) (25 mL) was added a catalytical amount of Raney-Ni and hydrazine hydrate (9.0 mmol) and the mixture was stirred at ambient temperature for 15 minutes, filtered through a Celite pad. The filtrate was evaporated to provide the title compound, (197 mg, 94%), which was used in further reactions without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07875728B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-aa1ebbc0bb594019973bea123e110b38 |
| 出典メモ | uspto-grants-2011_01 |