反应详情

2-Fluoro-4-nitrotoluene (1.55 g, 10 mmol), N-bromosuccinimide (1.82 g, 10 mmol), and benzoyl peroxide (0.1 g, 0.4 mmol) were dissolved in CCl4 (50 mL). The mixture was heated at reflux, and irradiated with light (100 W bulb) for 4 hours. The reaction mixture was filtered and concentrated. The residue was dissolved in THF (50 mL) and morpholine (1.9 g, 22 mmol) was added to this solution. The mixture was stirred at ambient temperature for 1 hour, and then filtered. The filtrate was evaporated. The title compound was isolated by column chromatography in an amount of 710 mg (30% yield).

1. temperatureThe mixture was heated
2. temperatureat reflux
3. customirradiated with light (100 W bulb) for 4 hours
4. filtrationThe reaction mixture was filtered
5. concentrationconcentrated
6. dissolutionThe residue was dissolved in THF (50 mL)
7. filtrationfiltered
8. customThe filtrate was evaporated