2-Aminothiazole → 3-(3-methoxypropyl)-1,3-thiazol-2(3H)-imine hydrobromide

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-aminothiazole (1.0 g, 10 mmol) and 1-bromo-3-methoxypropane (1.8 g, 12 mmol, commercially available from Aldrich) were heated at 85° C. for 16 hours. The solid was cooled to ambient temperature, triturated with ethanol, and then collected by filtration to afford 1.2 g (48%) of the title compound. MS (DCI/NH3) m/z 173 (M+H)+.

Provenance & Evidence