Ethyl 2-aminothiazole-4-carboxylate → Ethyl 2-imino-3-(2-methoxyethyl)-2,3-dihydro-1,3-thiazole-4-carboxylate hydrobromide

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Reaction Steps

2-Aminothiazole-4-carboxylic acid ethyl ester (17.2 g, 100 mmol) and 2-bromoethyl methyl ether (15.3 g, 110 mmol) were processed as described as described in Example 2A to afford 17.1 g (83%) of the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.30 (t, J=7 Hz, 3 H) 3.22 (s, 3 H) 3.60 (t, J=15 Hz, 2 H) 4.32 (t, J=7 Hz, 2 H) 4.35-4.61 (m, 2 H) 7.84 (s, 1 H) 9.76 (s, 1 H); MS (DCI/NH3) m/z 231 (M+H)+.

Provenance & Evidence