1-Adamantanecarboxylic acid → HCID 178435125, compound

Participants

Reaction Steps

4,5-Dimethylthiazol-2-ylamine, (2-Bromoethoxymethyl)-benzene and 1-adamantane carboxylic acid were processed as described in Example 47 to afford the title compound. 1H NMR (CDCl3, 300 MHz) δ ppm 1.58-1.73 (m, 6 H) 1.79 (d, J=2.50 Hz, 6 H) 1.91-2.02 (m, 3 H) 2.15 (s, 3 H) 2.22 (s, 3 H) 3.77 (t, J=5.46 Hz, 2 H) 4.29 (t, J=5.46 Hz, 2 H) 4.47 (s, 2 H) 7.19 (d, J=6.55 Hz, 2 H) 7.22-7.33 (m, 3 H); MS (ESI) m/z 425 (M=H)+.

Provenance & Evidence