2-Aminothiazole → HCID 131728626, compound

Participants

Reaction Steps

A solution of 2-aminothiazole (27 g, 0.27 mol) and bromo-acetic acid ethyl ester (36 mL, 0.32 mol) in 540 mL of acetone was heated at 50° C. for 6 hours. The mixture was concentrated under reduced pressure and the residue was triturated with ethanol. The solid was collected by filtration to provide 58 g (80%) of the title compound. 1H NMR (DMSO-d6, 300 MHz) δ ppm 1.25 (t, J=7.1 Hz, 3 H), 4.20 (q, J=7.1 Hz, 2 H), 5.00 (s, 2 H), 7.04 (d, J=4.7 Hz, 1 H), 7.38 (d, J=4.7 Hz, 1 H), 9.62 (s, 1 H).

Provenance & Evidence