2-Amino-4,5-dimethyl-1,3-thiazole → HCID 131728627, compound

HRID 255089Notes

Reaction equation

HRID 255089 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][Br:8])([CH3:4])([CH3:3])[CH3:2].[CH3:10][C:11]1[N:12]=[C:13]([NH2:17])[S:14][C:15]=1[CH3:16]>>[BrH:8].[C:1]([O:5][C:6](=[O:9])[CH2:7][N:12]1[C:11]([CH3:10])=[C:15]([CH3:16])[S:14][C:13]1=[NH:17])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 732382-Amino-4,5-dimethyl-1,3-thiazoleHCID 79177tert-Butyl bromoacetate

Product 1

HCID 131728627HCID 131728627, compound

Procedure

Bromoacetic acid tert-butyl ester (1.4 mL, 9.4 mmol) and 4,5-dimethyl-2-aminothiazole (1.0 g, 7.8 mmol) were heated at 85° C. for 14 hours. The mixture was cooled to ambient temperature and the resulting solid was triturated with ethyl acetate to provide the title compound.

Workup

  1. customthe resulting solid was triturated with ethyl acetate

Sources & evidence

ORD record
ord-b49f074bab07465fbfbe1c4307f836c4
Source dataset
uspto-grants-2011_01
Patent number
US07875639B2

Reaction notes

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