HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanamide → 5-(Oxan-4-yl)-1,3-thiazol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanamide | HCID 9864 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | Sulfur | HCID 5362487 | — |
| Reactant | 2-(Oxan-4-yl)acetaldehyde | HCID 17750943 | — |
| Product | 5-(Oxan-4-yl)-1,3-thiazol-2-amine | HCID 86619050 | — |
Reaction Steps
A mixture of (tetrahydro-pyran-4-yl)-acetaldehyde (Pharmacore), pyrrolidine, p-toluenesulfonic acid monohydrate, sulfur and cyanamide were processed using the method described in Example 136A to obtain the title compound. MS (ESI+) m/z 185 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07875639B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-fcf2b3caacdd4179823852464ad2a356 |
| Source note | uspto-grants-2011_01 |