HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 255134Generated: October 29, 2026
2-Amino-5-methylthiazole → Ammonium Hydroxide
https://huagongshe.com/reaction/255134
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Amino-5-methylthiazole | HCID 351770 | — |
| Reactant | HCID 66860330 | HCID 66860330 | — |
| Product | Ammonium Hydroxide | HCID 14923 | — |
| Product | 3-((1,4-dioxan-2-yl)methyl)-5-methylthiazol-2(3H)-imine | HCID 66861006 | — |
Reaction Steps
A mixture of 2-amino-5-methylthiazole (0.77 g, 8.8 mmol) and 2-iodo-methyl-1,4-dioxane (Synchem-OHG, 1.5 g, 6.7 mmol) was warmed to 85° C. and stirred for 16 hours. The mixture was cooled to ambient temperature and the residue was purified via column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2:methanol:NH4OH) to afford the title compound. MS (DCI/NH3) m/z 215 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07875639B2 |
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| Source dataset | uspto-grants-2011_01 |
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| ORD ID | ord-31ee29ed428b4a2aa47b4a4f3839a992 |
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| Source note | uspto-grants-2011_01 |
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