HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(5,6-difluoro1H-indol-2-yl)-2-methoxy-phenylamine → (4-{3-[5-(5,6-Difluoro-1h-indol-2-yl)-2-methoxy-phenyl]-thioureido}-benzyl)-phosphonic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(5,6-difluoro1H-indol-2-yl)-2-methoxy-phenylamine | HCID 9943439 | — |
| Reactant | Diethyl 4-isothiocyanatobenzylphosphonate | HCID 22568434 | — |
| Product | (4-{3-[5-(5,6-Difluoro-1h-indol-2-yl)-2-methoxy-phenyl]-thioureido}-benzyl)-phosphonic acid diethyl ester | HCID 87999803 | — |
Reaction Steps
The product from Example 3, 5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenylamine, (0.137 g, 0.5 mmol) was reacted with the product from Example 23, Step A (0.156 g, 0.54 mmol) according to the procedure for Example 23, Step B to give the product (0.172 g), mp 180-182° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06858739B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-fdf2a18672704ebf834b4895c6e25952 |
| Source note | uspto-grants-2005_02 |