HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminum(III) Chloride → 7,8-Difluoroquinolin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 7-Bromoquinolin-2(1H)-one | HCID 14221025 | — |
| Reactant | (2E)-N-(2,3-difluorophenyl)-3-phenylacrylamide | HCID 47450756 | — |
| Product | 7,8-Difluoroquinolin-2(1H)-one | HCID 64208671 | — |
Reaction Steps
The compound was prepared from (2E)-N-(2,3-difluorophenyl)-3-phenylacrylamide (Intermediate 22) (7.4 g, 28.5 mmol) and aluminium trichloride (19 g, 142 mmol) as described for Intermediate 17. The crude cyclization product was obtained as a single regioisomer, which was used without further purification, 2 g light brown solid (37%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07875715B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-3092021686104b8a9f1c2d003bb94370 |
| Source note | uspto-grants-2011_01 |