HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminum(III) Chloride → 5,7-Difluoro-1,2-dihydroquinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | HCID 17271861 | HCID 17271861 | — |
| Reactant | 7,8-Difluoroquinolin-2(1H)-one | HCID 64208671 | — |
| Product | 5,7-Difluoro-1,2-dihydroquinolin-2-one | HCID 64208249 | — |
Reaction Steps
The compound was prepared from (2E)-N-(3,5-difluorophenyl)-3-phenylacrylamide (Intermediate 26) (8.1 g, 31.2 mmol) and aluminium trichloride (21 g, 156 mmol) in a similar way as described for Intermediate 21. 3.47 g light brown solid (61%), mp 292-318° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07875715B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-d0a2ca0a36e34e86af971ccd477f06f9 |
| Source note | uspto-grants-2011_01 |