HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Lutidine → (2E)-N-(3-fluorophenyl)-3-phenyl-2-propenamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Lutidine | HCID 7937 | — |
| Reactant | 3-Fluoroaniline | HCID 9742 | — |
| Reactant | 3-Phenylprop-2-enoyl chloride | HCID 66023 | — |
| Reactant | (2E)-N-(3-bromophenyl)-3-phenylprop-2-enamide | HCID 874919 | — |
| Product | (2E)-N-(3-fluorophenyl)-3-phenyl-2-propenamide | HCID 727184 | — |
Reaction Steps
The compound was prepared from 3-fluoroaniline (5.8 mL, 60 mmol) and cinnamoylchloride (10 g, 60 mmol) in the presence of 2,6-lutidine (10.5 mL, 90 mmol) as described for Intermediate 18 to give a colorless solid, 13.9 g (96%), mp 110° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07875715B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-e5b43bf397a24970984723678ea01866 |
| Source note | uspto-grants-2011_01 |