6-methoxy-3,4-dihydro-2H-1,4-benzoxazin-3-one → HCID 11788809, compound

HRID 255207Notes

Reaction equation

HRID 255207 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][CH2:10][C:11](OCC)=[O:12])=[C:5]([N+:16]([O-])=O)[CH:4]=1.COC1C=CC2OCC(=O)NC=2C=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]2[S:9][CH2:10][C:11](=[O:12])[NH:16][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 132049526-methoxy-3,4-dihydro-2H-1,4-benzoxazin-3-oneHCID 13690743HCID 13690743, compound2×

Product 1

HCID 11788809HCID 11788809, compound

Procedure

Prepared from ethyl [(4-methoxy-2-nitrophenyl)thio]acetate (Intermediate 53, 3 g, 11 mmol) according to procedure described for preparation of Intermediate 48. Silica gel chromatography with hexanes/ethyl acetate (3:2) afforded desired product, 2 g (93%).

Sources & evidence

ORD record
ord-2a13854608d4435eab387983f3d0db51
Source dataset
uspto-grants-2011_01
Patent number
US07875715B2

Reaction notes

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