1-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrile → HCID 66775194, compound

HRID 255218Notes

Reaction equation

HRID 255218 reaction equation
[O:1]=[C:2]1[N:7]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([NH:16]C(=O)OC(C)(C)C)[CH2:12][CH2:11]2)[C:6]2[CH:24]=[C:25]([O:28][C:29]([F:32])([F:31])[F:30])[CH:26]=[CH:27][C:5]=2[O:4][CH2:3]1.NC1CCN(CCN2C3C(=CC=C(C#N)C=3)C=CC2=O)CC1>>[NH2:16][CH:13]1[CH2:12][CH2:11][N:10]([CH2:9][CH2:8][N:7]2[C:6]3[CH:24]=[C:25]([O:28][C:29]([F:32])([F:31])[F:30])[CH:26]=[CH:27][C:5]=3[O:4][CH2:3][C:2]2=[O:1])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 602009201-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrileHCID 86664536HCID 86664536, compound2×

Product 1

HCID 66775194HCID 66775194, compound

Procedure

tert-Butyl (1-{2-[3-oxo-6-(trifluoromethoxy)-2,3-dihydro-4H-1,4-benzoxazin-4-yl]ethyl}piperidin-4-yl)carbamate (Intermediate 62) (790 mg, 1.72 mmol) was reacted as described for Intermediate 14. The crude trifluoro acetate of the title compound was used without further purification for the next step (quantitative yield).

Workup

  1. customThe crude trifluoro acetate of the title compound was used without further purification for the next step (quantitative yield)

Sources & evidence

ORD record
ord-e46aa155d0ca45e2a80e9c8cffb692a4
Source dataset
uspto-grants-2011_01
Patent number
US07875715B2

Reaction notes

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