反应详情

6-[({1-[2-(6-Acetyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)ethyl]piperidin-4-yl}amino)methyl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one (Example 45) (309 mg, 0.645 mmol) was reduced with sodium borohydride (47 mg, 2 equivalents) in methanol (12 mL) at 0° C. After quenching the reaction with water, the reaction mixture was concentrated under reduced pressure and extracted with chloroform. The chloroform layer was washed with brine and dried over magnesium sulfate and concentrated to dryness to give the as an off-white solid, 202 mg (95%).

1. customAfter quenching
2. customthe reaction with water
3. concentrationthe reaction mixture was concentrated under reduced pressure
4. extractionextracted with chloroform
5. washThe chloroform layer was washed with brine
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated to dryness
8. customto give the as an off-white solid, 202 mg (95%)