1-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrile → HCID 66775170, compound

HRID 255268Notes

Reaction equation

HRID 255268 reaction equation
[CH2:1]([S:3]([C:6]1[CH:7]=[CH:8][C:9]2[O:14][CH2:13][C:12](=[O:15])[N:11]([CH2:16][CH2:17][N:18]3[CH2:23][CH2:22][CH:21]([NH:24]C(=O)OC(C)(C)C)[CH2:20][CH2:19]3)[C:10]=2[CH:32]=1)(=[O:5])=[O:4])C.NC1CCN(CCN2C3C(=CC=C(C#N)C=3)C=CC2=O)CC1>>[NH2:24][CH:21]1[CH2:22][CH2:23][N:18]([CH2:17][CH2:16][N:11]2[C:10]3[CH:32]=[C:6]([S:3]([CH3:1])(=[O:5])=[O:4])[CH:7]=[CH:8][C:9]=3[O:14][CH2:13][C:12]2=[O:15])[CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 602009201-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrileHCID 86642630HCID 86642630, compound2×

Product 1

HCID 66775170HCID 66775170, compound

Procedure

tert-Butyl (1-{2-[6-(ethylsulfonyl)-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]ethyl}piperidin-4-yl)carbamate (Intermediate 104) was reacted as described for Intermediate 14. The crude trifluoro acetate of the title compound was obtained as a colorless solid and used without further purification for the next step (quantitative yield).

Sources & evidence

ORD record
ord-0c8696b9d6a84a26b9a3c0de9bf38134
Source dataset
uspto-grants-2011_01
Patent number
US07875715B2

Reaction notes

Loading…