HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl oxoacetate → 7,8-Difluoroquinoxalin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl oxoacetate | HCID 70211 | — |
| Reactant | 3,4-Difluorobenzene-1,2-diamine | HCID 2736753 | — |
| Reactant | 6,7-Difluoro-1,2-dihydroquinoxalin-2-one | HCID 6324339 | — |
| Reactant | 5,6-difluoroquinoxalin-2(1H)-one | HCID 66775376 | — |
| Product | 7,8-Difluoroquinoxalin-2(1H)-one | HCID 66773436 | 64.3% |
Reaction Steps
3,4-Difluorobenzene-1,2-diamine (4.6 g, 31.6 mmol) and ethyl oxoacetate (50 wt % in toluene, 13.0 mL, 63.2 mmol) were reacted as described for Intermediate 152 to give 3.7 g of product as an off white solid, mixture with 30% of the regioisomer 5,6-difluoroquinoxalin-2(1H)-one. The mixture was carried on to the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07875715B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-b452eb5bfcf7484e963a655f25c3e386 |
| Source note | uspto-grants-2011_01 |